Hepatitis in children: Previous Kovid-19 infection may be responsible Health

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Ômicron’s new subvariant, XE looks more contagious, but WHO is still not concerned

The prevalence of hepatitis in children, which has already caused more than 300 cases worldwide, according to the World Health Organization (WHO), continues the conspiracy of experts who have not yet discovered the cause of inflammation in the liver. Although the most common hypothesis is that an adenovirus – a pathogen that causes common colds – is behind the disease, it is still unclear why these routine agents cause such serious and unintended consequences. This Friday, researchers at Imperial College London, United Kingdom, and Cedars Sinai Medical Center in the United States published an article in the scientific journal The Lancet Gastroenterology and Hepatology that points to an answer and reinforces the theory that previous infections by SARS. CoV-2, the virus that causes Covid-19, may be involved.

Hepatitis cases reported so far have tested negative for the traditional viruses that cause inflammation: A, B, C, D and E. So, since the reporting began in April, experts have sought an explanation for the mystery. Based on laboratory tests, the British Health Organization’s main estimate is that the cause is adenovirus 41F, a pathogen detected in 72% of children diagnosed with inflammation in the UK. However, they still consider the possibility that the problem is a post-infection syndrome caused by Covid-19, an effect that would be limited to Ômicron variants. According to researchers, both estimates may be correct.

The new article points to the possibility that SARS-Cavi-2 has a long-lasting effect on the body, which in turn increases inflammation when children become infected with the adenovirus. They explain that the Covid-19 virus creates reservoirs that survive the infection in the gastrointestinal tract and can lead to the repeated release of viral proteins that activate immune cells.

This recurrence will be associated with SARS-Cavi-2, which has an effect called a superAntigen, which stimulates certain viruses or bacteria in some people to do much more than the normal concentration of immune T cells. The problem is that this abnormally high population of immune system cells causes a cascade of inflammatory events in the body.

Researchers have identified that a region of the Sars-CoV-2 spike protein stimulates this super antigen behavior. This increased immune cell activation has even been suggested as a cause of multisystem inflammatory syndrome in children with Covid-19, which was identified in 2020.

Based on these findings, British researchers theorize that the antigen effect of SARS-Cavi-2, associated with the formation of reservoirs in the intestinal tract, may create a favorable environment for post-covid inflammation. This will lead to a much more aggressive and harmful reaction by the body when the baby is infected with adenovirus – resulting in hepatitis.

“We estimate that the recently reported incidence of severe acute hepatitis in children may be the result of adenovirus infection with intestinal (tissue) trophism in children with previously SARS-CoV-2 and viral reservoirs,” the researchers wrote.

This thesis is particularly strong because, in Israel, 11 out of 12 children infected with hepatitis tested positive for Covid-19. Experts noted, however, that any association with the vaccine was ruled out, as in most cases children under 5 years of age, the public is still not eligible to be vaccinated.

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